CIPHER, which stands for Correlating interactome and phenome networks to predict disease genes, is a computational framework we proposed to prioritize human disease genes. It was one of the first studies to explore interactome-phenome wide gene-disease relationships, and generated the first comprehensive genetic landscape of human disease,connecting 5080 human disease phenotypes with 14433 human genes.
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Mol Syst Biol. 2008;4:189. doi: 10.1038/msb.2008.27. Epub 2008 May 6.
Network-based global inference of human disease genes.
Wu X1, Jiang R, Zhang MQ, Li S.