ChargeCzar uses a support vector machine to discriminate between +2- and +3-charged tandem mass spectra, with the goal of reducing database search time by eliminating the need to search twice with each spectrum.
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Peptide charge state determination for low-resolution tandem mass spectra
Aaron Klammer, Christine C. Wu, Michael J. MacCoss and William Stafford Noble
Proceedings of the Computational Systems Bioinformatics Conference 2005