CentroidFold predicts an RNA secondary structure from an RNA sequence. FASTA and one-sequence-in-a-line format are accepted for predicting a secondary structure per sequence. It also predicts a consensus secondary structure when a multiple alignment (CLUSTALW format) is given. CentroidFold based on a generalized centroid estimator is one of the most accurate tools for predicting RNA secondary structures. See the original paper for the details of the algorithm.
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Kengo Sato, Michiaki Hamda, Kiyoshi Asai, Toutai Mituyama,
CentroidFold: a web application for RNA secondary structure prediction,
Nucl. Acids Res. (2009) 37 (suppl 2): W277-W280