BSubtilis is the ABM ( Agent Based Model) designed to mimic the B. subtilis competence phenotype. The model was tuned to simulate a colony of B. subtilis cells where competence emerged in 10–20% of the population. BSubtilis make the following observations and predictions about genetic “noise”: a) random spatial-temporal interactions lead to competence, b) daughter cells which inherit portions of the competence machinery are more likely to exhibit the competence phenotype, and c) dilution events like cell division inhibit competence emergence until stationary phase.
The Giddings Lab at Boise State
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Theor Biol Med Model. 2013 Apr 3;10:23. doi: 10.1186/1742-4682-10-23.
Agent-based modeling of competence phenotype switching in Bacillus subtilis.
Stiegelmeyer SM, Giddings MC.