Br2 (Bias-Reduced estimates via Bootstrap Resampling) is a software designed to estimate bias-corrected OR and BETA values for association studies. The bootstrap method used is computationally intensive, however br2 can analyze most GWAS datasets and obtain point estimates in a few hours on a modern machine.
- Linux / Windows / MacOsX
- C Compiler
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BR-squared: a practical solution to the winner’s curse in genome-wide scans.
Sun L, Dimitromanolakis A, Faye LL, Paterson AD, Waggott D; DCCT/EDIC Research Group, Bull SB.
Hum Genet. 2011 May;129(5):545-52