Bisulfighter is a software package for detecting methylated cytosines (mCs) and differentially methylated regions (DMRs) from bisulfite sequencing data. Compared with other published tools, Bisulfighter provides greater sensitivity for mCs with fewer false positives, more precise estimates of mC levels, more exact locations of DMRs, and better agreement of DMRs with differentially expressed genes. The superior accuracy is maintained under various sequencing depths and tissue types.
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Nucleic Acids Res. 2014 Apr 1;42(6):e45. doi: 10.1093/nar/gkt1373. Epub 2014 Jan 13.
Bisulfighter: accurate detection of methylated cytosines and differentially methylated regions.
Saito Y1, Tsuji J, Mituyama T.