The BiSeq (Bisulfite sequencing) package provides useful classes and functions to handle and analyze targeted bisulfite sequencing (BS) data such as reduced-representation bisulfite sequencing (RRBS) data. In particular, it implements an algorithm to detect differentially methylated regions (DMRs).
- R package
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Bioinformatics. 2013 Jul 1;29(13):1647-53. doi: 10.1093/bioinformatics/btt263. Epub 2013 May 8.
Detection of significantly differentially methylated regions in targeted bisulfite sequencing data.
Hebestreit K, Dugas M, Klein HU.