The BCL (Bio Chemical Library) is a software package that provides unique tools for biological research, such as protein structure determination from sparse experimental data.The BCL contains the widely used secondary structure prediction program JUFO, a folding algorithm that assembles secondary structure elements, and loop construction tools that complete protein backbones. With this series of protocols the BCL allows construction of backbone models for large and membrane proteins from the primary sequence. Among its unique strengths are the incorporation of sparse and low resolution data into folding simulations.Additionally, the BCL contains a suite of cheminformatics tools that allow construction of quantitative structure-activity-relation (QSAR) models for virtual screening, pharmacophore mapping, and drug design.
- Windows / Linux / MacOsX
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BCL::Fold – De Novo Prediction of Complex and Large Protein Topologies by Assembly of Secondary Structure Elements.
Karakaş M, Woetzel N, Staritzbichler R, Alexander N, Weiner BE, Meiler J.
PLoS One. 2012;7(11):e49240. doi: 10.1371/journal.pone.0049240. Epub 2012 Nov 16.