BALM ( bi-asymmetric-Laplace model) was developed to analyze MBD-seq. We compared the resolution of BALM to that of several ChIP-seq analysis tools. The results demonstrate the program’s superior ability to distinguish methylation statuses of closely positioned CpG sites. This study demonstrates that MBD-seq combined with the new program is potentially a powerful tool to capture genome-wide DNA methylation profiles with high efficiency and resolution.
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Lan X, Adams C, Landers M, Dudas M, Krissinger D, et al. (2011)
High Resolution Detection and Analysis of CpG Dinucleotides Methylation Using MBDSeq Technology.
PLoS ONE 6(7): e22226. doi:10.1371/journal.pone.0022226