BALBOA is an ORF (Open Reading Frame) annotation approach, in which classifiers are constructed from the class specific expression patterns discovered by bicluster analysis. Firstly a set of bicluster classifiers is build using a labelled training set from the annotated ORFs in the expression data. These biclusters are then used to classify an unlabelled ORF set i.e. the unannotated ORFs from the expression dataset.
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BMC Genomics. 2008 Sep 16;9 Suppl 2:S20.
Extending bicluster analysis to annotate unclassified ORFs and predict novel functional modules using expression data.
Bryan K, Cunningham P.