ATRIUM is a C++ program that performs case-control association testing between a binary trait and an untyped SNP, based on genotype data from multiple typed SNPs that are in linkage disequilibrium with the untyped SNP, where information on the joint distribution of typed and untyped SNPs is obtained from an external reference panel. A special feature of ATRIUM is that both related and unrelated individuals can be included in the case-control sample. The user specifies a set of untyped SNPs on which external reference panel information is available, and the ATRIUM program computes a test statistic for association with each untyped SNP in the set. This test is suitable for case-control analysis in any outbred sample with related and/or unrelated individuals, including large pedigrees, provided that the relationships are known.
Zuoheng Wang and Mary Sara McPeek
- Linux / Windows / MacOsX
- C Compier
:: MORE INFORMATION
Wang, Z., and McPeek, M.S. (2009).
ATRIUM: Testing untyped SNPs in case-control association studies with related individuals.
Am. J.Hum. Genet. 85, 667-678.