ATHENA (the Analysis Tool for Heritable and Environmental Network Associations) results in clear performance improvements for discovering gene-gene interactions that influence human traits. We employed an alternative tree-based crossover, backpropagation for locally fitting neural network weights, and incorporation of domain knowledge obtainable from publicly accessible biological databases for initializing the search for gene-gene interactions. We tested these modifications in silico using simulated datasets.
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ATHENA: A knowledge-based hybrid backpropagation-grammatical evolution neural network algorithm for discovering epistasis among quantitative trait Loci.
Turner SD, Dudek SM, Ritchie MD.
BioData Min. 2010 Sep 27;3(1):5.