ASP / ASPHARE
ASP is a power calculator for gene mapping using a sibpair design (concordant or discordant). ASP employs a diallelic model for the trait locus and simulates parental and offspring genotypes under Hardy-Weinberg equilibrium. Marker locus genotypes are simulated conditional upon the inheritance pattern at the trait locus and tested for non-Mendelian ibd sharing. For discordant sibs, an unrestricted likelihood ratio test is used; for affected sibpairs, the power of the dataset is also determined using a restricted likelihood ratio test.
ASPSHARE complements ASP in that it allows rapid calculation of the expected ibd sharing at the trait locus, based upon the model parameters, and the incidence corresponding to the respective parameters. It should therefore be used prior to any time-consuming simulations to assess whether a model is sensibel.
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