ARTO (Analysis of Replication Timing and Organization) uses signal processing methods to fit a constant piece-wise linear curve to the measured raw data. The software takes raw time of replication (ToR) measurement signals as input and outputs for each genomic location an estimate of its ToR and an association to CTR (constant ToR region) or TTR (Temporal Transition Region).
Laboratory of Computational Biology at the Technion.
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Systematic determination of replication activity type highlights interconnections between replication, chromatin structure and nuclear localization.
Farkash-Amar S, David Y, Polten A, Hezroni H, Eldar YC, Meshorer E, Yakhini Z, Simon I.
PLoS One. 2012;7(11):e48986.