ALBERT (A Likelihood-Based Estimation of Risk in Trios) is a C program that estimates genotype relative risks, genotyping error rates and population risk allele frequencies from marker genotype data in case-parent trios. ALBERT uses the distribution of trio marker genotypes to compute maximum likelihood estimates for the parameters. Complete instructions for running the program can be found in the documentation “albert.pdf” which can be downloaded here. Briefly, ALBERT runs on unix and requires two files, a marker file and a pedigree file (in LINKAGE format). The user must specify the names of these files on the command line, as well as the name of an output file that ALBERT will create. Finally, the user must specify one of the two available error models which are described in the documentation.
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