The project AhoPro was created to seach for overrepresentation of given motifs in DNA sequences and to search for motif cooccurrence. This could discover the synergy of transcription factors (TF), which usually takes place in regulatory modules of genes.
Laboratory of bioinformatics , State Research Institute of Genetics And Selection of Industrial Microorganism
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Algorithms Mol Biol. 2007 Oct 10;2:13.
Exact p-value calculation for heterotypic clusters of regulatory motifs and its application in computational annotation of cis-regulatory modules.
Boeva V, Clément J, Régnier M, Roytberg MA, Makeev VJ.