Agos is an alignment-free approach to detect Argonaute-binding WG/GW domains in protein sequence. The identification method is based on the amino-acid composition specificity of the domain. The initial sequence dataset of experimentally-confirmed AGO-binding proteins was used to introduce two-parameter scoring system that help to discriminate genuine GW repeat proteins.
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Bioinformatics. 2011 May 1;27(9):1318-9. doi: 10.1093/bioinformatics/btr128. Epub 2011 Mar 8.
Agos–a universal web tool for GW Argonaute-binding domain prediction.
Zielezinski A1, Karlowski WM.