Agene automatically generates a species-specific gene predictor from a set of reliable mRNA sequences and a genome.Author applies a Hidden Markov model (HMM) that implements explicit length distribution modelling for all gene structure blocks using acyclic discrete phase type distributions. The state structure of the each HMM is generated dynamically from an array of sub-models to include only gene features represented in the training set.
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BMC Bioinformatics. 2006 May 21;7:263.
Automatic generation of gene finders for eukaryotic species.
Munch K, Krogh A.