ADMIXMAP is a general-purpose program for modelling admixture, using marker genotypes and trait data on a sample of individuals from an admixed population (such as African-Americans), where the markers have been chosen to have extreme differentials in allele frequencies between two or more of the ancestral populations between which admixture has occurred. The main difference between ADMIXMAP and classical programs for estimation of admixture such as ADMIX is that ADMIXMAP is based on a multilevel model for the distribution of individual admixture in the population and the stochastic variation of ancestry on hybrid chromosomes. This makes it possible to model the associations of ancestry between linked marker loci, and the association of a trait with individual admixture or with ancestry at a linked marker locus.
- Linux /MacOsX / Windows
- R package
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Design and analysis of admixture mapping studies.
Hoggart CJ, Shriver MD, Kittles RA, Clayton DG, McKeigue PM.
Am J Hum Genet. 2004 May;74(5):965-78. Epub 2004 Apr 14.